When the disease goes beyond the skin, changes in the skin can be a sign of systemic disease

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Abstract

Infantile hemangioma may be accompanied by malformations of internal organs and blood vessels. In 1996 PHACE syndrome was defined as a disease which is characterized by the association of segmental infantile hemangioma with localization in the head/neck region and the presence of malformations in the posterior cranial fossa, abnormalities of arterial blood vessels including coarctation of the aorta, heart defects, as well as malformations of the eyes and central nervous system. This article presents a clinical case of a child who was diagnosed this syndrome at the age of 1.5 months based on the presence of segmental hemangioma, as well as large and small criteria specific for this disease. In addition to the main symptoms, the child had an accompanying pathology: Wolff–Parkinson–White syndrome. Therapy with non-selective b-blockers and polychemotherapy allowed stopping already developed and prevent possible complications associated with this syndrome. Parents gave their consent to use information about the child, including fotos, in the article.

About the authors

L. A. Khachatryan

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: lili.2510@yandex.ru
ORCID iD: 0000-0001-7265-0414

cand. med. sci., Head of Box Department of Hematology/Oncology,

117997, Moscow, Samory Mashela st., 1

Russian Federation

D. M. Nikolaeva

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-4367-5975
117997, Moscow, Samory Mashela st., 1 Russian Federation

A. P. Shcherbakov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8129-0545
117997, Moscow, Samory Mashela st., 1 Russian Federation

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