Current trends in blood coagulation studies

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Abstract

Blood coagulation occurs in flow or stasis conditions, it involves components of cell hemostasis and enzymatic cascades of reactions; it serves to stop bleeding yet it can lead to life-threatening blood thrombi. Despite the fact that a complete list of coagulation proteins was well known for decades, in recent years numerous facts has accumulated about its structure and regulation. All that has led to the creation of new methods for diagnosing of blood coagulation disorders and methods for their correction. Congenital and acquired coagulation disorders are still an acute clinical problem. This review shows modern ideas about the structure and functioning of the blood coagulation system in various conditions.

About the authors

A. M. Shibeko

Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences;
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: alshibeko@gmail.com
ORCID iD: 0000-0003-1494-3125

PhD, leading researcher, laboratory of biophysics, 

117997, Moscow, Samory Mashela st., 1

Russian Federation

A. N. Balandina

Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences;
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation

117997, Moscow, Samory Mashela st., 1 Russian Federation

N. A. Podoplelova

Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences;
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0001-8013-1112
117997, Moscow, Samory Mashela st., 1 Russian Federation

M. A. Panteleev

Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences;
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0002-8128-7757
117997, Moscow, Samory Mashela st., 1 Russian Federation

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