А сlinical case report of mediastinal teratoma in an adolescent patient with Klinefelter syndrome

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Abstract

Teratoma is a germ cell tumor, which consists of derivatives of three germ layers and has various malignant potentials – from benign mature forms to immature embryonic forms with a somatic type of malignancy. Even the mature type of teratoma is biologically unpredictable providing for an ability to grow locally with invasion. Necessity for complete removal of tumors, wherever they are located, is explained by the fact that there is a risk of a possible development of growing teratoma syndrome or transformation into malignant tumors. This article describes the clinical case of growing teratoma syndrome of mediastinal localization in a teenager with Klinefelter syndrome, also as an example of the multidisciplinary approach of pediatric oncologists, surgeons, radiotherapists and pathomorphologists in decision-making for optimal treatment. The patients' parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

About the authors

S. S. Saliyeva

Scientific Center of Pediatrics and Pediatric Surgery

Author for correspondence.
Email: symbatsaliyeva@gmail.com
ORCID iD: 0000-0003-0262-8515

Symbat S. Saliyeva, a physician at the Oncology Department №2

46 Al-Farabi Avenue, Almaty A15E2P4

Kazakhstan

R. Z. Boranbayeva

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0002-7154-6436
Almaty Kazakhstan

B. M. Zhumadullayev

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0002-0882-7323
Almaty Kazakhstan

K. E. Khairov

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0002-5735-4032
Almaty Kazakhstan

E. V. Krivenko

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0002-1263-249X
Almaty Kazakhstan

A. Sh. Tainekova

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0003-2725-9920
Almaty Kazakhstan

A. N. Bekisheva

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0002-3595-5574
Almaty Kazakhstan

M. K. Karazhanova

Scientific Center of Pediatrics and Pediatric Surgery

ORCID iD: 0000-0001-6889-0749
Almaty Kazakhstan

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Copyright (c) 2025 Saliyeva S.S., Boranbayeva R.Z., Zhumadullayev B.M., Khairov K.E., Krivenko E.V., Tainekova A.S., Bekisheva A.N., Karazhanova M.K.

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