Choroid plexus carcinoma in children

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Abstract

Choroid plexus carcinomas (CPCs) are rare pediatric tumors with a generally poor prognosis. Currently there is no definite optimal treatment strategy for this neoplasm. This study is supported by the Independent Ethics Committee and approved by the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. This study included patients with a verified diagnosis of CPC at the age 0 to 18 years in the period from 01.01.2009 to 31.12.2019. A total of 32 patients were registered. The median age was 2.65 years; 93.5% of CPCs were localized in the lateral ventricles. Initial metastases were found in 21.8% of cases; 5-year event-free survival (EFS) in children with metastases was lower than in those who did not have metastases 29 ± 17% and 49 ± 12%. In our cohort, gross total resection (GTR) was performed in 65.6% of patients. The five-year EFS in patients with complete CPC removal was higher than in patients who underwent subtotal and partial resection (63 ± 13%, 12 ± 11%, and 0%, respectively). In addition, overall survival (OS) was slightly higher in those who underwent GTR compared with subtotal and partial resection (74 ± 12%, 67 ± 16%, and 0%, respectively). Of the 32 children with CPCs, 15 children received programm chemotherapy, 17 non-programm chemotherapy, 5-year EFS in patients who received programm and non-programm chemotherapy was 79 ± 11% and 0%, respectively (p = 0.0006), 5-year OS in patients who received programm and non-programm chemotherapy was 93 ± 7% and 36 ± 14% (p = 0.0054). 

About the authors

A. F. Valiakhmetova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation;
N.N. Burdenko National Medical Research Center of Neurosurgery

Author for correspondence.
Email: andgeval@gmail.com
ORCID iD: 0000-0002-2977-665X

a junior researcher at the Department of Treatment Optimization for CNS Tumours;

a pediatric oncologist at the 1st Department of Neurosurgery,

1 Samory Mashela St., Moscow 117997

Russian Federation

L. I. Papusha

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7750-5216

Moscow

Russian Federation

A. V. Sanakoeva

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-5893-0508

Moscow

Russian Federation

L. V. Shishkina

N.N. Burdenko National Medical Research Center of Neurosurgery

ORCID iD: 0000-0001-7045-7223

Moscow

Russian Federation

O. I. Budanov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-3232-2322

Moscow

Russian Federation

G. A. Novichkova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-2322-5734

Moscow

Russian Federation

S. K. Gorelyshev

N.N. Burdenko National Medical Research Center of Neurosurgery

ORCID iD: 0000-0003-0984-2039

Moscow

Russian Federation

A. I. Karachunskiy

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Moscow

Russian Federation

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Copyright (c) 2021 Valiakhmetova A.F., Papusha L.I., Sanakoeva A.V., Shishkina L.V., Budanov O.I., Novichkova G.A., Gorelyshev S.K., Karachunskiy A.I.

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