Email this article MRI T2*-mapping for liver iron assessment in pediatric patients with secondary iron overload
- Authors: Nazarova E.E.1, Tereshchenko G.V.1, Abakumov M.A.2, Smantser V.A.1, Kupriyanov D.A.3, Smetanina N.S.4
-
Affiliations:
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
- Oncology and radiotherapy Russian National Research Medical University named after N.I. Pirogov
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation Philips Healthcare
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation Oncology and radiotherapy Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 16, No 3 (2017)
- Pages: 23-27
- Section: Статьи
- Submitted: 10.08.2018
- Published: 10.08.2017
- URL: https://hemoncim.com/jour/article/view/64
- DOI: https://doi.org/10.24287/1726-1708-2017-16-3-23-27
- ID: 64
Cite item
Full Text
Abstract
Iron accumulation assessment in the body is important for iron overload determination in parenchymal organs and also necessary for planning and monitoring the chelation therapy. In this article, we demonstrate non-invasive diagnostics of iron accumulation in the liver using magnetic resonance imaging. MRI investigation includes 55 patients (2–18 years, median 8 years) with secondary iron overload due to regular blood transfusions. Image analysis was conducted by special program of signal decay evaluation for automatically T2* values calculation in liver. We have received a linear regression equation between the biopsy data and T2* values and have obtained the grading system of T2* values based on siderosis grades. Non-invasive MRI diagnostics in patients with iron overload can introduce new approaches for quantitative estimation of body iron deposition.
Keywords
About the authors
E. E. Nazarova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: evelina.nazarova@fcchomoscow.ru
ORCID iD: 0000-0002-0014-9345
research assistant, radiology. Department of information technologies’ development
Russia 117997, Moscow, Samory Mashela st., 1 Tel.: +7 (495) 287-6570, ext. 1223
Russian FederationG. V. Tereshchenko
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0001-7317-7104
Russian Federation
M. A. Abakumov
Oncology and radiotherapy Russian National Research Medical University named after N.I. Pirogov
ORCID iD: 0000-0003-2622-9201
Department of Hematology Russian Federation
V. A. Smantser
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationRussian Federation
D. A. Kupriyanov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationPhilips Healthcare
ORCID iD: 0000-0002-5662-896X
Russian Federation
N. S. Smetanina
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationOncology and radiotherapy Russian National Research Medical University named after N.I. Pirogov
ORCID iD: 0000-0002-8805-1499
Department of Hematology Russian Federation
References
Supplementary files
