Spindle cell neoplasm harboring MAPK signaling pathway gene translocation from the spectrum of NTRK-rearranged spindle cell tumor

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Abstract

Definition of novel nosological entities based on specific genetic aberrations is becoming more common tendency regarding neoplasms of all sites. Diagnostic approach to such entity represents an urgent issue of modern oncopathology due to the importance of further accurate genetic examination. NTRK-rearranged spindle cell neoplasm is one of such categories and includes a broad spectrum of entities with similar morphology and immunophenotype. Due to the recognition of a variety of related genes and their anomalies, as well as overlapping pathomorphological criteria, the diagnosis NTRK-rearranged spindle cell neoplasia may be an outstanding issue. Based on the clinical case, a possible algorithm of diagnostic approach to this entity is suggested in this article. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

About the authors

A. V. Tarakanova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: sequaciou@gmail.com
ORCID iD: 0000-0002-9496-3136

Alexandra V. Tarakanova, a resident in Anatomical Pathology

117997, Moscow, Samory Mashela St., 1

Russian Federation

A. S. Sharlay

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-5354-7067

Moscow

Russian Federation

A. V. Panferova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-8580-3499

Moscow

Russian Federation

I. V. Sidorov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8578-6572

Moscow

Russian Federation

D. M. Konovalov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7732-8184

Moscow

Russian Federation

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Copyright (c) 2022 Tarakanova A.V., Sharlay A.S., Panferova A.V., Sidorov I.V., Konovalov D.M.

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