Email this article Sarcoma with BCOR gene alterations (BCOR-ITD) of the L3 vertebra in an 8-year-old boy
- Authors: Sidorov I.V.1, Fedorova A.S.2, Makarova N.P.1, Konopleva E.I.1, Sharlai A.S.1, Panferova A.V.1, Druy A.E.1, Konovalov D.M.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
- Lomonosov Moscow State University
- Issue: Vol 21, No 3 (2022)
- Pages: 84-89
- Section: CLINICAL OBSERVATIONS
- Submitted: 15.10.2022
- Accepted: 15.10.2022
- Published: 15.10.2022
- URL: https://hemoncim.com/jour/article/view/654
- DOI: https://doi.org/10.24287/1726-1708-2022-21-3-84-89
- ID: 654
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Abstract
In the 2020 World Health Organization classification, for the first time, three new groups of tumors were formalized, initially isolated from the group of undifferentiated round cell sarcomas, the so-called Ewing-like sarcomas, namely sarcoma with BCOR genetic alterations, CIC-rearranged sarcoma and sarcomas with EWSR1 gene rearrangement with atypical (non-ETS family) partner genes. This review will focus on sarcoma with BCOR genetic alterations, which will be illustrated by one of our clinical case, characterized by relatively typical features, both in terms of morphological presentation and immunophenotype, and in terms of biological behavior and response to tumor therapy. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.
About the authors
I. V. Sidorov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: ilya93sidorov@gmail.com
ORCID iD: 0000-0001-8578-6572
Ilya V. Sidorov, a pathologist at the Department of Anatomic Pathologic
1 Samory Mashela St., 117997, Moscow, Russia
Russian FederationA. S. Fedorova
Lomonosov Moscow State University
ORCID iD: 0000-0002-4699-1730
Moscow
Russian FederationN. P. Makarova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3387-3567
Moscow
Russian FederationE. I. Konopleva
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-6848-8714
Moscow
Russian FederationA. S. Sharlai
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-5354-7067
Moscow
Russian FederationA. V. Panferova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-8580-3499
Moscow
Russian FederationA. E. Druy
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-1308-8622
Moscow
Russian FederationD. M. Konovalov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7732-8184
Moscow
Russian FederationReferences
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