The electron microscopy contribution to platelet structural pathology investigation

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Abstract

This article discusses the role of electron microscopy in the diagnosis and study of morphological changes that cause platelet structural abnormalities in a variety of congenital diseases. Morphological abnormalities can be divided into the abnormalities of the platelet cytoskeleton, of alpha and dense granules, and membrane abnormalities. Our paper describes ultrastructural platelet defects in Wiskott–Aldrich syndrome, MYH9-associated syndromes, gray platelet syndrome, Hermansky–Pudlak syndrome, Paris–Trousseau syndrome, Chediak–Higashi syndrome.

About the authors

S. I. Obydennyi

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation; Center for Theoretical Problems of Physicochemical Pharmacology, RAS

Author for correspondence.
Email: sergey.obidenniy@fccho-moscow.ru
ORCID iD: 0000-0002-2930-8768

Sergey I. Obydennyi, a researcher at the Laboratory of Cell Hemostasis and Thrombosis

1 Samory Mashela St., Moscow 117997, Russia

Russian Federation

I. I. Kireev

Lomonosov Moscow State University

ORCID iD: 0000-0001-9252-6808

Moscow

Russian Federation

M. A. Panteleev

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation; Center for Theoretical Problems of Physicochemical Pharmacology, RAS; Lomonosov Moscow State University

ORCID iD: 0000-0002-8128-7757

Moscow

Russian Federation

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Copyright (c) 2022 Obydennyi S.I., Kireev I.I., Panteleev M.A.

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