The effectiveness of the respiratory muscles in children with oncohematological diseases after hematopoietic stem cell transplantation

Cover Page

Cite item

Full Text

Abstract

   The article analyzes the effectiveness of the respiratory muscles by measuring inspiratory mouth occlusion pressure at 0.1 seconds during quiet breathing (P0.1) and maximum voluntary ventilation maneuver (P0.1max) in children with acute leukemia and acquired idiopathic aplastic anemia after allogeneic hematopoietic stem cell transplantation (HSCT). We carried out a comparative analysis of the Р0.1 and Р0.1max values measured before HSCТ and on days +30, +90, +180 and +360. In a group of patients with acquired idiopathic aplastic anemia, we revealed a significant decrease in these values starting from day +30, followed by a recovery to baseline values by one year of follow-up. In children with acute leukemia, effectiveness of the respiratory muscles was increased after 360 days of transplantation as a result of the aggravation of impaired ventilation. This method for measuring airway occlusion pressure can be used in a comprehensive assessment of the functional state of the respiratory system for the timely diagnosis of pulmonary complications after HSCT. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation.

About the authors

T. V. Kudinova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: tatyana.kudinova@fccho-moscow.ru
ORCID iD: 0000-0001-5608-8097

Tatiana V. Kudinova, Head of the Department, medical doctor

Department of Functional Diagnosis and Imaging of the Russkoe Pole Treatment and Rehabilitation Center

Department of Functional Diagnosis

Moscow

117997

1 Samory Mashela St.

Moscow

Russian Federation

Yu. V. Skvortsova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-0566-053X

Moscow

Russian Federation

D. E. Bostanov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; National Medical Research Center for Children’s Health of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-9577-8717

Moscow

Russian Federation

О. F. Lukina

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Email: oflukina@yandex.ru

Moscow

Russian Federation

E. A. Tikhomirova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-9652-4113

Moscow

Russian Federation

D. N. Balashov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-2689-0569

Moscow

Russian Federation

L. N. Shelikhova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-0520-5630

Moscow

Russian Federation

A. F. Karelin

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-6383-2822

Moscow

Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Kudinova T.V., Skvortsova Y.V., Bostanov D.E., Lukina О.F., Tikhomirova E.A., Balashov D.N., Shelikhova L.N., Karelin A.F.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.