Email this article Acute graft-versus-host disease after allogeneic stem cell transplantation from a haploidentical donor with post-transplant cyclophosphamide administration
- Authors: Bazaev A.A.1, Kozlovskaya S.N.1, Sultanova E.R.1, Skvortsova Y.V.1
-
Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
- Issue: Vol 22, No 2 (2023)
- Pages: 98-103
- Section: CLINICAL OBSERVATIONS
- Submitted: 07.03.2023
- Accepted: 23.05.2023
- Published: 08.07.2025
- URL: https://hemoncim.com/jour/article/view/728
- DOI: https://doi.org/10.24287/1726-1708-2023-22-2-98-103
- ID: 728
Cite item
Full Text
Abstract
Allogeneic hematopoietic stem cell transplantation is the only curative treatment for many life-threatening diseases. Due to the difficulty of finding an HLA-identical donor, transplantation from a haploidentical donor has become a frequent alternative. This option is associated with a higher risk of graft-versus-host disease (GVHD). In this article, we present the current view on the pathogenesis, treatment and prevention of GVHD and report a clinical case of acute GVHD after allogeneic hematopoietic stem cell transplantation from a haploidentical donor with post-transplant cyclophosphamide prophylaxis. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
About the authors
A. A. Bazaev
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0967-395X
Moscow
Russian FederationS. N. Kozlovskaya
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-1754-1220
Moscow
Russian FederationE. R. Sultanova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0319-3699
Moscow
Russian FederationYu. V. Skvortsova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: yuscvo@mail.ru
ORCID iD: 0000-0002-0566-053X
Yulia V. Skvortsova, Dr. Med. Sci., hematologist, Deputy Head of Department
Hematopoietic Stem Cell Transplantation Department № 2
Moscow
Russian FederationReferences
Supplementary files
