Dabigatran etexilate: a new oral anticoagulant

Cover Page
  • Authors: Sinauridze E.I.1, Vuimo T.A.2, Ataullakhanov F.I.3
  • Affiliations:
    1. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Center for Theoretical Problems of Physicochemical Pharmacology
    2. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
    3. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Center for Theoretical Problems of Physicochemical Pharmacology Department of Physics, Moscow State University
  • Issue: Vol 16, No 3 (2017)
  • Pages: 92-104
  • Section: Статьи
  • Submitted: 10.08.2018
  • Published: 10.08.2017
  • URL: https://hemoncim.com/jour/article/view/75
  • DOI: https://doi.org/10.24287/1726-1708-2017-16-3-92-104
  • ID: 75

Cite item

Full Text

Abstract

The article presents a review of the data about a new oral anticoagulant dabigatran etexilate (DE), which is the pro-drug, but in the body converts after oral administration in the active compound, a direct low-molecular weight thrombin inhibitor dabigatran. The major properties of dabigatran and DE, pharmacokinetic parameters of the preparation and its interactions with the other drugs are examined. Efficiency and safety of this preparation's clinical use in different pathological states are discussed also. The review of pharmacodynamics and the methods for measurement of the DE anticoagulant activity are  presented. The possible advantages of DE compare to other anticoagulants are discussed, also as the questions of clinical trials of DE for using in pediatric population.

About the authors

E. I. Sinauridze

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Center for Theoretical Problems of Physicochemical Pharmacology

Author for correspondence.
ORCID iD: 0000-0002-5948-3444

PhD, Leading Researcher, Laboratory of Biophysics

Senior Researcher, Laboratory of the Molecular Mechanisms of Hemostasis, Center for Theoretical Problems of Physicochemical Pharmacology

Russia, 117997, Moscow, Samory Mashela st., 1

Russian Federation

T. A. Vuimo

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology

ORCID iD: 0000-0003-3491-1884
Russia, 117997, Moscow, Samory Mashela st., 1 Russian Federation

F. I. Ataullakhanov

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Center for Theoretical Problems of Physicochemical Pharmacology
Department of Physics, Moscow State University

ORCID iD: 0000-0003-3403-181X
Russia, 117997, Moscow, Samory Mashela st., 1 Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Sinauridze E.I., Vuimo T.A., Ataullakhanov F.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.