Intracranial mesenchymal tumors with FET–CREB fusion

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Abstract

Intracranial mesenchymal tumors with rearrangements of the genes of the FET and CREB families were first described in the 2021 World Health Organization classification of tumors of the central nervous system. At the moment, the criteria for the diagnosis and treatment of these tumors have not been unambiguously defined. This article presents two exceptionally rare clinical cases of adolescent patients with IMT with the presence of gene rearrangement of the FET and CREB gene families, who were treated and examined at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The patients’ parents gave consent to the use of their children's data, including photographs, for research purposes and in publications.

About the authors

V. A. Degtyarev

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: degtyarev.vitaly@yandex.ru
ORCID iD: 0000-0002-9722-4590

Vitaly A. Degtyarev, a pediatric oncologist at the Department of Adolescent  Hematology/Oncology and Neuro-oncology

1 Samory Mashela St., Moscow 117997

Russian Federation

A. V. Panferova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-8580-3499

Moscow

Russian Federation

M. A. Zaitseva

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-2015-5790

Moscow

Russian Federation

A. E. Druy

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation;
Research Institute of Medical Cell Technologies

ORCID iD: 0000-0003-1308-8622

Moscow;

Yekaterinburg

Russian Federation

K. Yu. Sinichenkova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-1661-4205

Moscow

Russian Federation

Yu. M. Mareeva

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Moscow

Russian Federation

V. Yu. Roshchin

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Moscow

Russian Federation

A. V. Artemov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Moscow

Russian Federation

L. I. Papusha

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7750-5216

Moscow

Russian Federation

References

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Copyright (c) 2023 Degtyarev V.A., Panferova A.V., Zaitseva M.A., Druy A.E., Sinichenkova K.Y., Mareeva Y.M., Roshchin V.Y., Artemov A.V., Papusha L.I.

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This work is licensed under a Creative Commons Attribution 4.0 International License.