Current views on the etiology and pathogenesis of ALK-positive anaplastic large cell lymphoma

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Abstract

   ALK-positive anaplastic large cell lymphoma is a mature T-cell lymphoma characterized by translocations that involve the ALK receptor tyrosine kinase coding gene. This illness is known to almost exclusively affect children and young adults. The biology of ALK-positive anaplastic large cell lymphoma is fairly well researched today, with recent studies focusing on the histogenesis of this neoplasm. In this review, we analyze the existing world literature data on the etiology and pathogenesis of this disease.

About the authors

D. S. Abramov

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian Federation

Author for correspondence.
Email: abramovd_s@bk.ru
ORCID iD: 0000-0003-3664-2876

Dmitry S. Abramov, MD, a pathologist

Pathology Department

117997; 1 Samory Mashela St.; Moscow

Russian Federation

A. S. Fedorova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian Federation

ORCID iD: 0000-0002-4699-1730

Moscow

Russian Federation

E. V. Volchkov

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian Federation; Research Institute of Molecular and Cellular Medicine of the Patrice Lumumba Рeoples’ Friendship University of Russia

ORCID iD: 0000-0002-2574-1636

Moscow

Russian Federation

N. V. Myakova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian Federation

ORCID iD: 0000-0002-4779-1896

Moscow

Russian Federation

D. M. Konovalov

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian Federation; Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7732-8184

Moscow

Russian Federation

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