Email this article Allogeneic hematopoietic stem cell transplantation for relapsed/refractory non-Hodgkin lymphomas
- Authors: Sergeenko K.A.1, Kirgizov K.I.1, Machneva E.B.1,2, Burlaka N.A.1, Potemkina T.I.1, Mitrakov K.V.1, Elfimova A.Y.1, Smirnova D.S.1, Malova M.D.1, Lozovan Y.V.1, Fatkhullin R.R.1, Stepanyan N.G.1, Aliev T.Z.1, Kostareva I.O.1, Skvortsova Y.V.3, Kozlov A.V.4, Batmanova N.A.1, Matinyan N.V.1, Gorbunova T.V.1, Valiev T.T.1, Varfolomeeva S.R.1
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Affiliations:
- The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
- Russian Children's Clinical Hospital of the N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation,
- The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
- The R.M. Gorbacheva Research Institute for Pediatric Oncology, Hematology and Transplantation, the I. P. Pavlov First Saint-Petersburg State Medical University of Ministry of Healthcare of the Russian Federation
- Issue: Vol 23, No 2 (2024)
- Pages: 152-157
- Section: CLINICAL OBSERVATIONS
- Submitted: 06.03.2024
- Accepted: 08.04.2024
- Published: 08.07.2025
- URL: https://hemoncim.com/jour/article/view/825
- DOI: https://doi.org/10.24287/1726-1708-2024-23-2-152-157
- ID: 825
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Abstract
Treatment of non-Hodgkin lymphomas (NHL) in children using risk-based chemotherapy protocols is currently effective in 80–95% of cases, even in advanced stages of the disease. However, relapsed/refractory forms of NHL (which are less common) have an extremely unfavorable course with low survival rates. The addition of autologous and allogeneic hematopoietic stem cell transplantation (HSCT) to a comprehensive treatment program for relapsed/refractory forms of NHL can improve treatment results due to the antitumor effect of chemotherapy drugs of the conditioning regimen and the graft-versus-tumor effect, which is, however, less significant than in leukemia. Moreover, post-transplant complications after allogeneic HSCT in some cases can offset its positive results in NHL; therefore, to reduce toxicity, especially in severe somatic status of the patient, preference is often given to reduced-intensity conditioning regimens. This article presents two clinical cases. In one case, autologous HSCT was carried out for the first relapse of Burkitt's lymphoma. However, the patient developed a second relapse and underwent allogeneic HSCT from a haploidentical donor. In the second case, HSCT from an unrelated HLA identical donor was carried out in a patient with relapsed anaplastic large cell lymphoma. Both patients received reduced-intensity conditioning regimens. This approach helped to avoid the development of severe post-transplant complications, ensuring successful engraftment and achievement of donor hematopoietic chimerism. Early after transplantation, the patient with relapsed Burkitt's lymphoma developed a second tumor – acute T-lymphoblastic leukemia, from which the patient died. Despite treatment with targeted drug crizotinib, the second patient showed lymphoma progression, which resulted in death. The patients' parents gave consent to the use of their children's data, including photographs, for research purposes and in publications.
About the authors
K. A. Sergeenko
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: karina_s19@mail.ru
ORCID iD: 0000-0003-3225-8412
Karina A. Sergeenko, a pediatric oncologist at the Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the L.A. Durnov Research Institute of Pediatric Oncology and Hematology of the N.N. Blokhin National Medical Research Center of Oncology
24 Kashirskoe Highway, 115522 Moscow, Russia
Russian FederationK. I. Kirgizov
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-2945-284X
Moscow
Russian FederationE. B. Machneva
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation;Russian Children's Clinical Hospital of the N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation,
ORCID iD: 0000-0003-2395-4045
Moscow
Russian FederationN. A. Burlaka
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3289-223X
Moscow
Russian FederationT. I. Potemkina
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0009-0007-0074-7197
Moscow
Russian FederationK. V. Mitrakov
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-2010-5534
Moscow
Russian FederationA. Yu. Elfimova
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-8143-5791
Moscow
Russian FederationD. S. Smirnova
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0009-0007-2171-1951
Moscow
Russian FederationM. D. Malova
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-9112-5973
Moscow
Russian FederationYu. V. Lozovan
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0600-8962
Moscow
Russian FederationR. R. Fatkhullin
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-5988-8428
Moscow
Russian FederationN. G. Stepanyan
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7939-5129
Moscow
Russian FederationT. Z. Aliev
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-1091-1521
Moscow
Russian FederationI. O. Kostareva
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0179-2479
Moscow
Russian FederationYu. V. Skvortsova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-0566-053X
Moscow
Russian FederationA. V. Kozlov
The R.M. Gorbacheva Research Institute for Pediatric Oncology, Hematology and Transplantation, the I. P. Pavlov First Saint-Petersburg State Medical University of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-4072-601X
Saint Petersburg
Russian FederationN. A. Batmanova
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3005-2085
Moscow
Russian FederationN. V. Matinyan
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7805-5616
Moscow
Russian FederationT. V. Gorbunova
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-5805-726X
Moscow
Russian FederationT. T. Valiev
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-1469-2365
Moscow
Russian FederationS. R. Varfolomeeva
The N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-6131-1783
Moscow
Russian FederationReferences
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