Therapy of childhood T-cell acute lymphoblastic leukemia: Experience gained by the Russian-Byelorussian cooperative group

G. R. Sharapova; Шарапова Гюзель Рафаиловна; Yu. V. Rumyantseva; Румянцева Юлия Васильевна; E. G. Boichenko; Бойченко Эльмира Госмановна; S. N. Lagoiko; Лагойко Светлана Николаевна; O. I. Bydanov; Быданов Олег Иванович; O. V. Aleinikova; Алейникова Ольга Витальевна; L. G. Fechina; Фечина Лариса Геннадьевна; O. R. Arakaev; Аракаев Олег Раисович; O. V. Streneva; Стренева Ольга Владимировна; A. V. Shamardina; Шамардина Анастасия Вячеславовна; D. V. Litvinov; Литвинов Дмитрий Витальевич; N. V. Myakova; Мякова Наталья Валерьевна; N. I. Ponomareva; Пономарева Наталья Игоревна; L. A. Khachatryan; Хачатрян Лили Альбертовна; E. A. Orlova; Орлова Елизавета Андреевна; K. L. Kondratchik; Кондратчик Константин Леонидович; E. G. Mansurova; Мансурова Екатерина Геннадьевна; L. M. Minkina; Минкина Людмила Михайловна; E. S. Lapotentova; Лапотентова Елена Сергеевна; L. V. Baidun; Байдун Людмила Васильевна; Yu. V. Olshanskaya; Ольшанская Юлия Вячеславовна; E. V. Inyushkina; Инюшкина Евгения Васильевна; N. B. Yudina; Юдина Наталья Борисовна; I. E. Gerbek; Гербек Инна Эмильевна; A. P. Shapochnik; Шапочник Александр Петрович; A. I. Karachunsky; Карачунский Александр Исаакович

doi:10.24287/1726-1708-2015-14-1-26-37

Therapy of childhood T-cell acute lymphoblastic leukemia: Experience gained by the Russian-Byelorussian cooperative group

Authors: Sharapova G.R.¹, Rumyantseva Y.V.²^,3, Boichenko E.G.⁴, Lagoiko S.N.², Bydanov O.I.²^,5, Aleinikova O.V.⁵, Fechina L.G.⁶, Arakaev O.R.⁷, Streneva O.V.⁶, Shamardina A.V.⁸, Litvinov D.V.²^,3, Myakova N.V.², Ponomareva N.I.⁹, Khachatryan L.A.², Orlova E.A.², Kondratchik K.L.³^,10, Mansurova E.G.³, Minkina L.M.⁷, Lapotentova E.S.⁵, Baidun L.V.⁹, Olshanskaya Y.V.², Inyushkina E.V.¹¹, Yudina N.B.¹², Gerbek I.E.¹³, Shapochnik A.P.¹⁴, Karachunsky A.I.²^,3
Affiliations:
1. Nizhnevartovsk Regional Pediatric Clinical Hospital
2. Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
3. Russian National Research Medical University named after N.I.Pirogov
4. Pediatric Municipal Hospital No. 1
5. Republican Center of Pediatric Oncology, Hematology, and Immunology
6. Regional Pediatric Clinical Hospital No 1
7. Regional Pediatric Clinical Hospital No. 1
8. Nizhny Novgorod Regional Pediatric Clinical Hospital
9. Russian Pediatric Clinical Hospital
10. Morozovskaya Pediatric Municipal Clinical Hospital
11. Moscow Regional Oncological Center
12. Voronezh Regional Pediatric Clinical Hospital No 1
13. Tomsk Regional Clinical Hospital
14. Orenburg Regional Clinical Oncological Center
Issue: Vol 14, No 1 (2015)
Pages: 26-37
Section: ОСТРЫЙ ЛИМФОБЛАСТНЫЙ ЛЕЙКОЗ
Submitted: 19.09.2018
Published: 19.02.2015
URL: https://hemoncim.com/jour/article/view/87
DOI: https://doi.org/10.24287/1726-1708-2015-14-1-26-37
ID: 87

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Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is a tumor developing as a result of malignant transformation of precursor T-cells. Despite the fact that T-ALL is responsible for about 10-15% of all ALL cases in children, it is essential to separate T-ALL in a special subgroup, as a nosological entity by the tumor biology, poor clinical outcome and resistance to therapy. We analyze the results of treatment of 644 patients with T-ALL, registered in the data base of the Russian-Byelorussian Research Group over 24 years of its work. The initial characteristics of the patients, responses to therapy, prognostic factors, and efficacy of various therapeutic options are analyzed.

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дети, Т-клеточный острый лимфобластный лейкоз, терапия, выживаемость, прогностические факторы, children, T-cell acute lymphoblastic leukemia, therapy, survival, prognostic factors

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Therapy of childhood T-cell acute lymphoblastic leukemia: Experience gained by the Russian-Byelorussian cooperative group

Full Text

Abstract

Keywords

About the authors

References

Supplementary files