Early T-cell precursor acute lymphoblastic leukemia

E. G. Boichenko; Бойченко Эльмира Госмановна; A. M. Popov; Попов Александр Михайлович; T. A. Makarova; Макарова Татьяна Александровна; N. N. Dokhina; Дохина Наталья Николаевна; I. A. Garbuzova; Гарбузова Ирина Анатольевна; O. V. Makarova; Макарова Ольга Владимировна; O. R. Arakaev; Аракаев Олег Раисович; L. G. Fechina; Фечина Лариса Геннадьевна; A. I. Karachunsky; Карачунский Александр Исаакович

doi:10.24287/1726-1708-2015-14-1-38-45

Early T-cell precursor acute lymphoblastic leukemia

Authors: Boichenko E.G.¹, Popov A.M.²^,3, Makarova T.A.¹, Dokhina N.N.¹, Garbuzova I.A.¹, Makarova O.V.², Arakaev O.R.², Fechina L.G.⁴^,3, Karachunsky A.I.⁵^,6
Affiliations:
1. Municipal Pediatric Hospital No. 1
2. Regional Pediatric Clinical Hospital No. 1
3. Institute of Medical Cell Technologies
4. Regional Pediatric Clinical Hospital No 1
5. Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
6. Russian National Research Medical University named after N.I.Pirogov
Issue: Vol 14, No 1 (2015)
Pages: 38-45
Section: ОСТРЫЙ ЛИМФОБЛАСТНЫЙ ЛЕЙКОЗ
Submitted: 19.09.2018
Published: 19.02.2015
URL: https://hemoncim.com/jour/article/view/88
DOI: https://doi.org/10.24287/1726-1708-2015-14-1-38-45
ID: 88

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Abstract

The transcription and immunological studies of the latest decade have shed new light on the biology of T-cell acute lymphoblastic leukemia (T-ALL) and identified a new T-ALL subtype - early T-cell precursor ALL (ETP-ALL), a tumor from immature hematopoietic precursors which retain their capacity to myeloid differentiation. Identification of the characteristic phenotype of immature T-lymphoblasts is extremely important for the diagnosis of ETP-ALL, when the risk of failure of therapy even by modern protocols is very high. By transcription ETP-ALL is closely related to hematopoietic stem cells and myeloid precursors. The available data indicate that use of drugs active in acute myeloid leukemia can improve the prognosis for patients with ETP-ALL. The unique biology of the tumor and the extremely unfavorable prognosis in ETP-ALL necessitate the creation of a new therapeutic strategy for the treatment of this disease. Two clinical case reports of ETP-ALL are presented, demonstrating variants of extremely unfavorable course of the disease and requiring individual therapeutic approaches.

Keywords

дети, острый лимфобластный лейкоз из ранних предшественников Т-клеток, ETP-лейкоз, ответ на терапию, индивидуализация терапии, children, early T-precursor acute lymphoblastic leukemia, ETP-ALL, response to therapy, individual therapy

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Early T-cell precursor acute lymphoblastic leukemia

Full Text

Abstract

Keywords

About the authors

References

Supplementary files