Email this article Thrombocytopenia of newborns: an observational study
- Authors: Suntsova E.V.1, Deripapa E.V.1, Raykina E.V.1, Mukhina A.A.1, Rodina Y.A.1, Baydildina D.D.1, Khachatryan L.A.1, Petrova U.N.1, Antonova K.S.1, Аbashidze Z.A.1, Fedorova D.V.1, Kieva A.M.1, Kurnikova M.A.1, Gaskova M.V.1, Maschan A.A.1
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Affiliations:
- The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
- Issue: Vol 23, No 4 (2024)
- Pages: 34-46
- Section: ORIGINAL ARTICLES
- Submitted: 04.09.2024
- Accepted: 07.11.2024
- Published: 13.12.2024
- URL: https://hemoncim.com/jour/article/view/885
- DOI: https://doi.org/10.24287/1726-1708-2024-23-4-34-46
- ID: 885
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Abstract
Thrombocytopenia is a common abnormality in neonates. The etiology of neonatal thrombocytopenia ranges from common acquired causes such as immune-mediated thrombocytopenia and sepsis to rare congenital syndromes. There may be objective difficulties in identifying the causes of thrombocytopenia in newborns in the clinical practice. All hematological and nonhematological features of a newborn and his family members must be taken into account for an accurate diagnosis. In our study, we analysed a cohort of 52 children with thrombocytopenia developed in the neonatal period and retrospectively assessed the range of their possible clinical diagnoses. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation. Perinatal infections and sepsis are often associated with thrombocytopenia. Immune thrombocytopenias are still “diagnoses of exclusion”. In 18 (34.6%) cases, molecular genetic testing confirmed rare congenital syndromes associated with thrombocytopenia. Despite various etiology, donor platelet transfusion with or without intravenous immunoglobulin remains the main treatment method of neonatal thrombocytopenia.
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About the authors
E. V. Suntsova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: elena.suncova@dgoi.ru
ORCID iD: 0000-0001-8404-1800
Elena V. Suntsova, a researcher of the Department of Bone Marrow Depression, Myeloid Leukemia, Rare and Hereditary Diseases
1 Samory Mashela St., Moscow 117997
Russian FederationE. V. Deripapa
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-9083-4783
Moscow
Russian FederationE. V. Raykina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-7634-2053
Moscow
Russian FederationA. A. Mukhina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Moscow
Russian FederationYu. A. Rodina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-9857-4456
Moscow
Russian FederationD. D. Baydildina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7130-8596
Moscow
Russian FederationL. A. Khachatryan
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7265-0414
Moscow
Russian FederationU. N. Petrova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-1258-8281
Moscow
Russian FederationK. S. Antonova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-6603-5749
Moscow
Russian FederationZ. A. Аbashidze
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-6314-2132
Moscow
Russian FederationD. V. Fedorova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-4567-1871
Moscow
Russian FederationA. M. Kieva
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-2467-2840
Moscow
Russian FederationM. A. Kurnikova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0900-6874
Moscow
Russian FederationM. V. Gaskova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3277-9018
Moscow
Russian FederationA. A. Maschan
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-0016-6698
Moscow
Russian FederationReferences
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