Email this article Thrombocytopenia of newborns: an observational study
- Authors: Suntsova E.V.1, Deripapa E.V.1, Raykina E.V.1, Mukhina A.A.1, Rodina Y.A.1, Baydildina D.D.1, Khachatryan L.A.1, Petrova U.N.1, Antonova K.S.1, Аbashidze Z.A.1, Fedorova D.V.1, Kieva A.M.1, Kurnikova M.A.1, Gaskova M.V.1, Maschan A.A.1
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Affiliations:
- The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
- Issue: Vol 23, No 4 (2024)
- Pages: 34-46
- Section: ORIGINAL ARTICLES
- Submitted: 04.09.2024
- Accepted: 07.11.2024
- Published: 13.12.2024
- URL: https://hemoncim.com/jour/article/view/885
- DOI: https://doi.org/10.24287/1726-1708-2024-23-4-34-46
- ID: 885
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Abstract
Thrombocytopenia is a common abnormality in neonates. The etiology of neonatal thrombocytopenia ranges from common acquired causes such as immune-mediated thrombocytopenia and sepsis to rare congenital syndromes. There may be objective difficulties in identifying the causes of thrombocytopenia in newborns in the clinical practice. All hematological and nonhematological features of a newborn and his family members must be taken into account for an accurate diagnosis. In our study, we analysed a cohort of 52 children with thrombocytopenia developed in the neonatal period and retrospectively assessed the range of their possible clinical diagnoses. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation. Perinatal infections and sepsis are often associated with thrombocytopenia. Immune thrombocytopenias are still “diagnoses of exclusion”. In 18 (34.6%) cases, molecular genetic testing confirmed rare congenital syndromes associated with thrombocytopenia. Despite various etiology, donor platelet transfusion with or without intravenous immunoglobulin remains the main treatment method of neonatal thrombocytopenia.
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About the authors
E. V. Suntsova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: elena.suncova@dgoi.ru
ORCID iD: 0000-0001-8404-1800
Elena V. Suntsova, a researcher of the Department of Bone Marrow Depression, Myeloid Leukemia, Rare and Hereditary Diseases
1 Samory Mashela St., Moscow 117997
РоссияE. V. Deripapa
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-9083-4783
Moscow
РоссияE. V. Raykina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-7634-2053
Moscow
РоссияA. A. Mukhina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Moscow
РоссияYu. A. Rodina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-9857-4456
Moscow
РоссияD. D. Baydildina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7130-8596
Moscow
РоссияL. A. Khachatryan
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-7265-0414
Moscow
РоссияU. N. Petrova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-1258-8281
Moscow
РоссияK. S. Antonova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0001-6603-5749
Moscow
РоссияZ. A. Аbashidze
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-6314-2132
Moscow
РоссияD. V. Fedorova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-4567-1871
Moscow
РоссияA. M. Kieva
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-2467-2840
Moscow
РоссияM. A. Kurnikova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0900-6874
Moscow
РоссияM. V. Gaskova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3277-9018
Moscow
РоссияA. A. Maschan
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-0016-6698
Moscow
РоссияReferences
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