Acute myeloid leukemia with translocations involving the KMT2A gene in twins as a model for the study of leukemogenesis: clinical case reports and genetic characteristics

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Abstract

Familial cases of acute leukemia in children are very rare and are mainly reported in cases of genetically determined predisposition syndromes (mutations in the RUNX1, ETV6, ANKRD26, GATA2, SAMD9/SAMD9L, CEBPA genes) which have been well characterized in the last 15 years. In twins, leukemia is even more rare and is of particular interest for the study of leukemogenesis patterns and evolution of leukemic subclones. Here, we report about three pairs of twins: in one pair, KMT2A-r-leukemia was diagnosed simultaneously, while in the other two cases the second child remained healthy despite the development of KMT2A-r-leukemia in their twin. The patients’ parents gave consent to the use of their children's data, including photographs, for research purposes and in publications.

About the authors

Z. Z. Askerova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: azzi19.99@mail.ru
ORCID iD: 0009-0009-6838-0963

Zakhra Z. Askerova - a hematologist at the Inpatient Facility for Short-Term Treatment.

1 Samory Mashela St., 117997, Moscow

Russian Federation

E. A. Zerkalenkova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-9634-5828

Moscow

Russian Federation

S. A. Lebedeva

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-1719-1726

Moscow

Russian Federation

K. S. Iskakova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-6001-2746

Moscow

Russian Federation

D. A. Venyov

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-0183-1530

Moscow

Russian Federation

U. N. Petrova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-1258-8281

Moscow

Russian Federation

D. D. Baydildina

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7130-8596

Moscow

Russian Federation

D. N. Balashov

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-2689-0569

Moscow

Russian Federation

G. O. Bronin

Morozov Children’s Clinical Hospital of the Department of Health of Moscow

ORCID iD: 0000-0002-0694-3996

Moscow

Russian Federation

I. Ya. Tomilin

Morozov Children’s Clinical Hospital of the Department of Health of Moscow

ORCID iD: 0009-0000-1649-6774

Moscow

Russian Federation

M. V. Natrusova

Morozov Children’s Clinical Hospital of the Department of Health of Moscow

ORCID iD: 0000-0003-4244-7110

Moscow

Russian Federation

M. V. Gaskova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-3277-9018

Moscow

Russian Federation

O. I. Soldatkina

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

Moscow

Russian Federation

Yu. V. Olshanskaya

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-2352-7716

Moscow

Russian Federation

A. N. Kazakova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-1085-4646

Moscow

Russian Federation

A. M. Popov

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-0889-6986

Moscow

Russian Federation

S. A. Kashpor

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-5220-7412

Moscow

Russian Federation

M. E. Dubrovina

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8228-4876

Moscow

Russian Federation

T. V. Konyukhova

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-6271-7435

Moscow

Russian Federation

A. A. Maschan

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-0016-6698

Moscow

Russian Federation

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Copyright (c) 2025 Askerova Z.Z., Zerkalenkova E.A., Lebedeva S.A., Iskakova K.S., Venyov D.A., Petrova U.N., Baydildina D.D., Balashov D.N., Bronin G.O., Tomilin I.Y., Natrusova M.V., Gaskova M.V., Soldatkina O.I., Olshanskaya Y.V., Kazakova A.N., Popov A.M., Kashpor S.A., Dubrovina M.E., Konyukhova T.V., Maschan A.A.

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