Молекулярный патогенез T-лимфобластной лимфомы

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   Т-лимфобластная лимфома (Т-ЛБЛ) занимает одно из ведущих мест в структуре неходжкинских лимфом у детей. По классификации Всемирной организации здравоохранения 2022 г. Т-ЛБЛ и острый Т-лимфобластный лейкоз рассматриваются в рамках единой нозологической категории, так как они имеют один и тот же морфологический субстрат – предшественники Т-клеток. За последние годы в лечении этого заболевания достигнуты определенные успехи, однако прогноз при рецидивах и рефрактерном течении до сих пор остается крайне неблагоприятным. Одним из перспективных направлений, способных повысить эффективность терапии, является внедрение новых схем лечения, учитывающих молекулярно-генетические особенности данной опухоли. В настоящем обзоре подробно рассматриваются молекулярные аспекты патогенеза Т-ЛБЛ.

Об авторах

В. Р. Днепровский

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России

Email: dneprovsky.vladimir@mail.ru
ORCID iD: 0009-0002-3896-6612

Владимир Романович Днепровский

Москва

Россия

А. С. Фёдорова

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России

Email: fyodorova_hannah@mail.ru
ORCID iD: 0000-0002-4699-1730

Анна Сергеевна Фёдорова

Москва

Россия

Д. С. Абрамов

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России

Email: abramovd_s@bk.ru
ORCID iD: 0000-0003-3664-2876

Дмитрий Сергеевич Абрамов

Москва

Россия

Е. В. Волчков

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России; Научно-исследовательский институт молекулярной и клеточной медицины ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»

Автор, ответственный за переписку.
Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0002-2574-1636

Егор Васильевич Волчков, врач-гематолог

отдел исследования лимфом

117997; ул. Саморы Машела, 1; Москва

Россия

Н. В. Мякова

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России

Email: nmiakova@mail.ru
ORCID iD: 0000-0002-4779-1896

Наталья Валерьевна Мякова

Москва

Россия

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© Днепровский В.Р., Фёдорова А.С., Абрамов Д.С., Волчков Е.В., Мякова Н.В., 2024

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