Email this article The diagnostic value of presepsin as a marker for congenital infections in newborns
- Authors: Sharafutdinova D.R.1,2, Balashova E.N.1, Sukhova Y.V.1, Kessler Y.V.1, Kirtbaya A.R.1,2, Ryndin A.Y.1,2, Golubtsova Y.M.1,2, Shakin I.A.1, Solomonova A.V.3, Artamkina E.I.2, Ivanets T.Y.1, Ionov O.V.1,2, Zubkov V.V.1,2
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Affiliations:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation
- I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
- N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation
- Issue: Vol 21, No 1 (2022)
- Pages: 56-64
- Section: ORIGINAL ARTICLES
- Submitted: 21.09.2021
- Accepted: 18.10.2021
- Published: 01.12.2021
- URL: https://hemoncim.com/jour/article/view/534
- DOI: https://doi.org/10.24287/1726-1708-2022-21-1-56-64
- ID: 534
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Abstract
The identification of the earliest diagnostic markers for infections in newborns remains one of the priorities in neonatology. In our study, we aimed to assess the diagnostic value of presepsin (P-SEP) as a marker for congenital infections in newborn children. The study was prospective in design and took place from January 2020 to February 2021. We enrolled a total of 64 children with a gestational age of 24 to 40 weeks. The study was approved by the Biomedical Research Ethics Committee (Minutes No.12 of 17 November 2016) and the Scientific Council (Minutes No.19 of 29 November 2016) of the V.I. Kulakov NMRC OGP of Ministry of Healthcare of the Russian Federation. Written voluntary consent to the patients’ participation in the study was obtained from their legal representatives. The patients were divided into 2 groups: a group of interest consisting of newborn children with congenital infections (n = 30), and a control group comprising newborns without signs of infection (n = 34). The group of interest included children with congenital pneumonia (n = 25), urinary tract infections (n = 3), and infections specific to the perinatal period, without a focus of infection (n = 2). Gestational age and birth weight were comparable between the groups. No statistically significant differences in CRP levels, neutrophil counts, immature-to-total neutrophil ratios and lactate concentrations on days 1 and 3 of life were found between the two groups. In the group of interest, P-SEP on day 1 of life was significantly higher than in the control group (р = 0.015). Our findings suggested that P-SEP levels ≥ 481 pg/mL could predict a high risk of congenital infections in newborns. The sensitivity and specificity were 91.0% and 60.0% respectively. P-SEP levels determined in capillary blood were similar to those obtained from venous blood samples suggesting that either can be used for P-SEP measurement with equal success. P-SEP levels were shown to decrease by day 3 of life in the children with congenital infections who had been treated with antibiotics.
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About the authors
D. R. Sharafutdinova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
Author for correspondence.
Email: dikarush@gmail.com
ORCID iD: 0000-0001-9626-5481
Moscow
Russian FederationE. N. Balashova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation
Email: e_balashova@oparina4.ru
ORCID iD: 0000-0002-3741-0770
Moscow
Russian FederationYu. V. Sukhova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation
Email: j_bezzubenko@mail.ru
ORCID iD: 0000-0001-9657-5375
Moscow
Russian FederationYu. V. Kessler
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation
Email: y_kessler@oparina4.ru
Moscow
Russian FederationA. R. Kirtbaya
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
Email: a_kirtbaya@oparina4.ru
ORCID iD: 0000-0002-7628-8157
Moscow
Russian FederationA. Yu. Ryndin
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
Email: a_ryndin@oparina4.ru
ORCID iD: 0000-0001-5560-8759
Moscow
Russian FederationYu. M. Golubtsova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
Email: yugolubtsova@yandex.ru
ORCID iD: 0000-0002-2288-1721
Moscow
Russian FederationI. A. Shakin
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation
Email: i_shakin@oparina4.ru
Moscow
Russian FederationA. V. Solomonova
N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation
Email: snow-white-angel@mail.ru
Moscow
Russian FederationE. I. Artamkina
I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
ORCID iD: 0000-0002-2920-6382
Moscow
Russian FederationT. Yu. Ivanets
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation
Email: t_ivanets@oparina4.ru
ORCID iD: 0000-0002-7990-0276
Moscow
O. V. Ionov
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
Email: o_ionov@oparina4.ru
ORCID iD: 0000-0002-4153-133X
Moscow
Russian FederationV. V. Zubkov
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (the Sechenov University)
Email: v_zubkov@oparina4.ru
ORCID iD: 0000-0001-8366-5208
Moscow
Russian FederationReferences
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