Rosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy): personal observations and literature review

A. E. Rudneva; Руднева А. Е.; D. S. Abramov; Абрамов Д. С.; A. S. Sharlay; Шарлай А. С.; Yu. N. Likar; Ликарь Ю. Н.; I. N. Vorozhtsov; Ворожцов И. Н.; N. V. Myakova; Мякова Н. В.

doi:10.24287/1726-1708-2023-22-1-99-109

Rosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy): personal observations and literature review

Authors: Rudneva A.E.¹, Abramov D.S.¹, Sharlay A.S.¹, Likar Y.N.¹, Vorozhtsov I.N.¹, Myakova N.V.¹
Affiliations:
1. The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian Federation
Issue: Vol 22, No 1 (2023)
Pages: 99-109
Section: CLINICAL OBSERVATIONS
Submitted: 14.02.2022
Accepted: 28.02.2023
Published: 14.02.2023
URL: https://hemoncim.com/jour/article/view/697
DOI: https://doi.org/10.24287/1726-1708-2023-22-1-99-109
ID: 697

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Abstract

Rosai–Dorfman disease (RDD) is a rare histiocytic disorder, which occurs at any age, can affect almost any organs and tissues, does not have pathognomonic symptoms and could be confirmed only by histological examination of the affected tissue. The article describes the successful treatment of a child with RDD with lymph nodes, nasopharynx, subcutaneous tissue, spleen and bones involvement, by multistep surgical treatment and chemotherapy. A review of the literature is provided, including recommendations for the examination and treatment of patients with RDD. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.