Extracorporeal photopheresis: how, why and for whom?

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Abstract

   Extracorporeal photopheresis is a method of cell therapy that was developed and introduced into clinical practice of various specialties over 30 years ago but its mechanism of action, clinical application and the possibility of further modification are still on the minds of scientists around the world. Here we provide a review of the existing literature on the major critical aspects of the extracorporeal photopheresis technology as well as information on possible ways of modifying the method, the current understanding of its mechanism of effectiveness, the use in various diseases and pathological conditions and a list of possible side effects.

About the authors

I. B. Kumukova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; Kommunarka Multidisciplinary Clinical Center of the Department of Health of Moscow

Author for correspondence.
Email: irina.kumukova@fccho-moscow.ru
ORCID iD: 0000-0002-9881-1041

Irina B. Kumukova, Cand. Med. Sci., researcher, Head of Unit

Department of Treatment and Prophylaxis Optimization for HSCT complications

Transfusion Unit

117997

1 Samory Mashela St.

Moscow

Russian Federation

P. E. Trakhtman

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-0231-1617

Moscow

Russian Federation

E. E. Kurnikova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-4767-5382

Moscow

Russian Federation

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Copyright (c) 2025 Kumukova I.B., Trakhtman P.E., Kurnikova E.E.

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