Email this article Molecular biology of nephroblastoma in the context of kidney development
- Authors: Kislyak I.A.1, Druy A.E.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
- Issue: Vol 22, No 4 (2023)
- Pages: 151-157
- Section: LITERATURE REVIEW
- Submitted: 05.01.2024
- Accepted: 05.01.2024
- Published: 20.12.2023
- URL: https://hemoncim.com/jour/article/view/804
- DOI: https://doi.org/10.24287/1726-1708-2023-22-4-151-157
- ID: 804
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Abstract
This paper presents a literature review of nephroblastoma molecular biology. In this article, we explored protein-coding genes in which mutations are the most common cause of Wilms’ tumor. We analyzed the role of these genes both in normal renal development and in Wilms’ tumorigenesis. Our special attention was focused on the embryonic development of the kidneys and how mutations in certain genes can disrupt normal nephrogenesis leading to the emergence of nephroblastoma.
About the authors
I. A. Kislyak
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-6042-9795
Moscow
Russian FederationA. E. Druy
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: dr-drui@yandex.ru
ORCID iD: 0000-0003-1308-8622
Alexander E. Druy, Cand. Med. Sci., Head of the Laboratory of Molecular Oncology
1 Samory Mashela St., Moscow 117997
Russian FederationReferences
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